AF Santos, LK James, HT Bahnson, MH Shamji, NC Couto-Francisco, ... Journal of Allergy and Clinical Immunology 135 (5), 1249-1256, Clinical & Experimental Allergy 38 (7), 1074-1088. Since the major effector functions of IgG depend on immune complex binding to complement and Fcγ receptors, these unique features distinguish IgG4 as an anti‐inflammatory subclass. Chen JB, James LK, Davies AM, Wu YC, Rimmer J, Lund VJ, Chen JH, Chan YC, Sutton BJ, Chang TW, Kariyawasam HH, Gould HJ. KR James, T Gomes, R Elmentaite, N Kumar, EL Gulliver, HW King, ... Nuevos artículos relacionados con la investigación de este autor, Grass pollen immunotherapy induces mucosal and peripheral IL-10 responses and blocking IgG activity, Grass pollen immunotherapy: IL-10 induction and suppression of late responses precedes IgG4 inhibitory antibody activity, Long-term tolerance after allergen immunotherapy is accompanied by selective persistence of blocking antibodies, Grass pollen immunotherapy induces an allergen-specific IgA2 antibody response associated with mucosal TGF-β expression, IgG 4 inhibits peanut-induced basophil and mast cell activation in peanut-tolerant children sensitized to peanut major allergens, Update on mechanisms of allergen injection immunotherapy, Proinsulin peptide immunotherapy in type 1 diabetes: report of a first‐in‐man Phase I safety study, The IgE-facilitated allergen binding (FAB) assay: validation of a novel flow-cytometric based method for the detection of inhibitory antibody responses, Allergen specificity of IgG 4-expressing B cells in patients with grass pollen allergy undergoing immunotherapy, A tool kit for rapid cloning and expression of recombinant antibodies, Potential mechanisms for IgG4 inhibition of immediate hypersensitivity reactions, Aluminium hydroxide down‐regulates T helper 2 responses by allergen‐stimulated human peripheral blood mononuclear cells, IgE-facilitated antigen presentation: role in allergy and the influence of allergen immunotherapy, Serum immunologic markers for monitoring allergen-specific immunotherapy, Inhibition of allergen‐dependent IgE activity by antibodies of the same specificity but different class, Influence of seasonal exposure to grass pollen on local and peripheral blood IgE repertoires in patients with allergic rhinitis, Antibodies and superantibodies in patients with chronic rhinosinusitis with nasal polyps, IgE binds asymmetrically to its B cell receptor CD23, Structure of a patient-derived antibody in complex with allergen reveals simultaneous conventional and superantigen-like recognition, Distinct microbial and immune niches of the human colon. CXCR3 is involved with B‐ and T‐ cell migration toward inflamed tissue in response to inflammation‐related chemokines CXCL9, CXCL10, and CXCL11 [23-25]. Dr James obtained a BSc in Immunology from King’s College London in 2002. Cited by. Over the next four years, I obtained funding to support my research but I remained on short-term contracts and ultimately decided to start applying for permanent positions elsewhere. Santos AF, Barbosa-Morais NL, Hurlburt BK, Ramaswamy S, Hemmings O, Kwok M, O¿Rourke C, Bahnson HT et al.(2020). My former institute had a well-defined policy on maternity leave; staff were entitled to 52 weeks leave, of which the first 18 weeks was at full pay, the following 21 weeks at statutory maternity pay and the remaining 13 weeks unpaid. Antibodies and Superantibodies in Chronic Rhinosinusitis with Nasal Polyps. Although the cues that regulate plasma cell longevity are not fully determined, the GC environment is an important source of long‐lived plasma cells which, through expression of CXCR4, migrate to bone marrow (BM) in response to CXCL12. An important question then is whether the unique chemokine expression profile of IgG4+ B cells is a consequence of a more experienced B cell population that by design is less responsive to antigen than its "younger" IgG1+ counterparts. It is easy to focus on the negative impact that becoming a parent may have on scientific careers. Bucaite G, Kang-Pettinger T, Moreira J, Gould HJ, James LK, Sutton BJ, McDonnell JM(2019). doi: 10.1101/2020.04.28.054775. Data Manager. After two years I moved to a different lab to take up my second postdoc (2009-2010).
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